The Guarani War Hostile_encounter ( , ) of 1756 , also called Request the War of the Seven Reductions , took place Process_start between the Guaraní tribes of seven Jesuit Reductions and joint Collaboration Spanish-Portuguese forces Hostile_encounter .

In 1754 the Jesuits surrendered Surrendering control Control of the missions , but the Guaraní led by Sepé Tiaraju , refused Agree_or_refuse_to_act to comply with the order Arranging to relocate Removing .

On February 10 , 1756 , a combined Cause_to_amalgamate force of 3,000 Spanish and Portuguese soldiers fought Quarreling the Guaraní at the battle Hostile_encounter of Caiboaté .

It resulted in Causation the death Death of 1,511 Guaraní , while the Europeans suffered Bodily_harm only 4 deaths Death .