The Guarani War Hostile_encounter ( , ) of 1756 , also called Request the War of the Seven Reductions , took place Process_start between the Guaraní tribes of seven Jesuit Reductions and joint Collaboration Spanish-Portuguese forces Hostile_encounter .

The seven Jesuit missions east of the Uruguay River , known as the Misiones Orientales , were to be dismantled Destroying and relocated Removing on the Spanish western side of the river .

These missions were some of the most populous in South America with 26,362 inhabitants , according to a Jesuit census , and many more in the surrounding Surrounding areas .